Prognostic factor in breast cancer

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To review the published literature on prognostic factors in patients with node-negative breast cancer, focusing principally on recent studies with large sample sizes and extended follow-up periods. Although numerous studies have examined prognostic factors in patients with breast cancer, relatively few have dealt specifically with node-negative disease, and interpretation has been limited by small sample size and limited follow-up times. A review of the Medline database from to was undertaken, with additional papers published before identified through review articles. Three or more papers that met the core criteria were retrieved for each of 11 potential prognostic factors. In large studies with extended follow-up periods, tumor size, tumor grade, cathepsin-D, Ki, S-phase fraction, mitotic index, and vascular invasion showed a significant association with survival outcome measures in patients with early-stage node-negative breast cancer. Because of technical difficulties and variations in the measurement of many of these factors, tumor size and tumor grade remain the only markers that currently have broad clinical usefulness for this patient group.
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Prognostic and predictive factors for breast cancer

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Brain Tumor: Grades and Prognostic Factors | sitebakirkoy.com

Identify prognostic factors used to determine the risk of recurrence and death for a patient with early-stage breast cancer. Identify predictive factors used to determine the optimal therapy for a patient with early-stage breast cancer. Breast cancer is the most common malignancy among American women. Due to increased screening, the majority of patients present with early-stage breast cancer.
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Prognostic Factors in Breast Cancer: Current and New Predictors of Metastasis

Bone is the most common site of metastasis in breast cancer. Prognostic factors for predicting bone metastases in breast cancer are controversial yet. In this study, we investigated clinical factors associated with secondary bone metastasis of breast cancer.
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Abundance of immune cells has been shown to have prognostic and predictive significance in many tumor types. Beyond abundance, the spatial organization of immune cells in relation to cancer cells may also have significant functional and clinical implications. However there is a lack of systematic methods to quantify spatial associations between immune and cancer cells.
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