Vaginal ph and estrogen treatment

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For decades hormone therapy HT has been prescribed to treat the symptoms of menopause, such as vaginal dryness, itching and burning. Here we sought to compare the vaginal microbiomes of postmenopausal women who received low dose estrogen therapy to those of premenopausal and postmenopausal women, and to do so in conjunction with assessing the alleviation of symptoms associated with vaginal atrophy. In this study vaginal swab samples were obtained from 45 women who were classified as either premenopausal, postmenopausal, or postmenopausal and undergoing HT. The vaginal microbiomes of these women were characterized by 16S rRNA gene sequencing and bacterial abundances were quantified by qPCR. We found that the vaginal communities from our cohort could be divided into six clusters A-F based on differences in the composition and relative abundances of bacterial taxa.
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Vaginal Dryness: Medical Causes and Top Treatments

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Diagnosis and Treatment of Atrophic Vaginitis - American Family Physician

The most common symptoms of vaginal atrophy are dryness, irritation, and pain during intercourse. Although menopause is the most common cause, vaginal atrophy can result from anything that lowers estrogen production. That includes chemotherapy, radiation, removal of the ovaries during hysterectomy, and use of anti-estrogenic therapies such as aromatase inhibitors, tamoxifen Nolvadex , and drugs like leuprolide Lupron and nafarelin Synarel , which are used to treat fibroids and endometriosis. Unlike hot flashes, which usually subside with time, vaginal atrophy is likely to persist and become worse without treatment. Loss of estrogen decreases blood flow to the vagina, causing vaginal tissue to become thinner, drier, and less elastic.
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Vaginal Changes During Menopause: How To Overcome Them

The medical term for the thinning, drying, and inflammation of the vaginal tissue that is commonly called vaginal dryness is atrophic vaginitis. For women experiencing the disorder, the symptoms can be very uncomfortable. Vaginal dryness, with or without inflammation, most often results from lower than usual estrogen levels.
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Estrogen plays an important role in managing your reproductive system, but it also protects your bones and helps your skin heal from bruises and injury. This can happen for various reasons. For example, your estrogen production slows down as you get older. Some conditions can also affect your estrogen levels. If your estrogen levels are low, your doctor may prescribe hormone therapy to help replace your estrogen levels and ease symptoms.
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